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Human Endocannabinoid System.

I mentioned the Human Endocannabinoid System (ECS) in  a review post.  See it HERE!

In this post I want to explore that system and what it does.

      Human Endocannabinoid System. 1The Endocannabinoid System.

  • Research initially suggested endocannabinoid receptors were only present in the brain and nerves, but scientists later found that the receptors are present throughout the body, including our skin, immune cells, bone, fat tissue, liver, pancreas, skeletal muscle, heart, blood vessels, kidney, and gastrointestinal tract.  We now know, the endocannabinoid system is involved in a wide variety of processes, including pain, memory, mood, appetite, stress, sleep, metabolism, immune function, and reproductive function. Endocannabinoids are arguably one of the most widespread and versatile signaling molecules known to man.


Some of the benefits of CBD use include:

  • Digestive aid
  • Reducing convulsions, seizures, nausea & vomiting
  • Suppressing or  reducing muscle spasms
  • Promoting immune function
  • Supporting energy levels
  • Encouraging cell regeneration

About The ECS

Until the 1980’s, we were not even aware of this system. It was once believed that these receptors only existed in the brain but recent studies have found more. 

CB1 receptors are all over our central nervous system, our lungs, kidney, and liver.

CB2 receptors are in the circulatory system and the immune system. 

Human Endocannabinoid System. 2

Humans are not alone in having this system. It exists in many animals as well, including dogs and cats. 

Not only does ECS take in and utilize CBD, is also directs the body’s internally produced cannabinoids. 

That’s right. We make CBD in our bodies. It is a crucial component of internal cell communication, growth, repair, and immunity. Apparently, our internal cannabinoids help fight inflammation and regulate brain function. 

Medical Express states:

For two decades it has been known that the human body also produces its own cannabinoids. Like THC they can attach themselves to the receptors. 

The brain scientist Professor Andreas Zimmer from the Bonn Institute of Molecular Psychiatry is investigating what the function of this endocannabinoid system is. ‘Mice without CB1 receptors show psychological abnormalities,’ he explains. ‘By contrast, CB2 regulates the growth of bones, for example.’

However, according to these most recent results, endocannabinoids also seem to play an important part in regulating inflammation processes. As is often the case with important discoveries, coincidence was involved. In scientific experiments mice are given an ear clip, so that researchers can tell them apart.

‘In most cases the mice can handle this without problems,’ Dr. Meliha Karsak, a member of Professor Zimmer’s team, explains. ‘With our mice this was different. The skin around the ear clips became inflamed.’ 

There are genetically modified strains of mice in which both cannabinoid receptors are dysfunctional. ‘And it was in precisely these strains that the inflammation occurred,’ she explains.

 So, people (and mice) without an active ECS are not at optimal health, both physically and mentally. 

The British Pharmalogical Journal states:

  • * The presence of functional cannabinoid CB2 receptors in the CNS has provoked considerable controversy over the past few years. Formerly considered as an exclusively peripheral receptor, it is now accepted that it is also present in limited amounts and distinct locations in the brain of several animal species, including humans. Furthermore, the inducible nature of these receptors under neuroinflammatory conditions, in contrast to CB1, makes them attractive targets for the development of novel therapeutic approaches. In fact, the undesired psychoactive effects caused by CB1 activation have largely limited the clinical use of cannabinoid‐related compounds that act on these receptors. In this review some recent findings on the anti inflammatory properties of CB2receptors are presented, as well as new perspectives that have been obtained based on studies of human postmortem brain samples. In addition, various working hypotheses are also proposed and discussed. *

But Wait, There’s More!

CBD is not the only active cannabinoid.

There are over 85 cannabinoids that have been found in hemp with CBD just being one of them. Its popularity is due to it having a large range of benefits with little to no side effects. The fact that it doesn’t cause the typical psycho-active effects normally tied to marijuana is perhaps the largest appeal. Just think, you get all the benefits but can take it when you need to drive, go to work, and any other situation you need to have a clear head for.

  • Neurology & Cognitive Function
  • Immunity & Allergy Systems
  • Hip & Joint Mobility
  • Relaxation & Comfort
  • Everyday Health & Wellness
  • The ECS has a different response to each of these cannabinoids.

Human Endocannabinoid System. 3

CBDA is cannabidiolic acid, produced in the stems, leaves, and flowers. If CBDA is heated or exposed to ultraviolet light it breaks down into CBD. 


CBN is cannibinol, the first cannabinoid scientifically isolated and analyzed. CBN comes from heating THC or oxygen exposure. This is one of the compounds in hemp and marijuana that contribute to the “high” feeling gained from smoking cannabis. 


CBN can also occur naturally in older plants, but you cannot get high on CBN alone. It has no psychoactive properties on its own. 


CBG is cannabigerol, and non-psychoactive. CBG often makes up less than 1% of a plant’s total cannabinoids, but it is no less useful. 

CBC is cannabichomene and was discovered over fifty years ago. It is one of byproducts of CBDA, like THC and CBD. 


It’s not the “Quality” or “Cost” of the bottle of Hemp CBD that really matters. It’s actually the amount of CBDA and CBD that gets into your blood stream for delivery. That’s what really makes the difference!


When naturally occurring cannabidiolic acid (CBDA) is processed (heated) that’s when CBD is created. While CBD is amazing, CBDA has been found to have superior as well as more anti-inflammatory properties. It’s actually a potent COX2 inhibitor which uses the exact same mode of action as non-steroidal anti inflammatories.


Organic & Pure

CBDPure oils are made with non-GMO hemp, grown in Colorado by local farmers. The hemp oil is minimally processed by following the highest organic standards at every step of our growing, harvesting, and bottling process. When you buy a CBDPure product, you are buying the purest CBD oil from natural sources, that is 100% free of any synthetic or artificial ingredients. We test every batch of oil that we process to ensure that it meets the purity standards that we demand.

Human Endocannabinoid System. 4

It’s A Household Name

If you have not heard of CBD by now, don’t feel left out.  I am taking what I have learned at Wealthy Affiliate and applying it to the CBDPure Affiliate program. If you want to know more about either of these platforms, feel free to contact me or leave me a comment below.

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